Pepcid & Claritin for Perimenopause: What Actually Helps

The Pepcid + Claritin combo has been trending on TikTok as a perimenopause fix. The mechanism is real — estrogen fluctuations affect mast cell activation, and combined H1 + H2 blockade can take the edge off histamine symptoms. But pills aren't the whole answer. Here's the histamine-estrogen connection in plain terms, what the OTC combo actually does, and the root-cause work that addresses why the symptoms started in the first place.